Not All Growth Factors are Equal
December 3, 2015 | Posted by Bill O'Brien
Not all growth factors are equal is a guide to help people understand what types of growth factors are out there, what they are derived from and to dispel many misconceptions that people may have about them. We will talk about growth factors, where they are derived, confusion between growth factors and growth hormones, what people use growth factor serums for and what the future holds for them.
The common sources of Growth Factors typically used in skin care products are:
- Plant Derived,
- Human Adipose Tissue
- Platelet-rich plasma (PRP)
- Even snails
- Is there a difference between Human Growth Factors and Human Growth Hormone? YES. A growth factor (GF) is a naturally occurring substance capable of stimulating cellular growth,(2) proliferation and cellular differentiation. Usually a growth factor is a protein. Growth factors are important for regulating a variety of cellular processes. Human Growth Hormones is often referred to as HGH, the hormone is secreted by the pituitary gland, a pea-sized structure at the base of the brain, and helps bone, muscle and organs grow. The hormone is essential for children to grow normally. If a child doesn’t make enough of it and doesn’t get treatment, he or she will be extremely short. With treatment, the child can grow normally and reach a normal adult height. The amount produced by the body normally declines in middle age, which has led some people to wonder if it could reverse the aging process and might be a hormonal fountain of youth.(3)
- What is the definition of a stem Cell? Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. They are found in multicellular organisms. In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells—ectoderm, endoderm and mesoderm (see induced pluripotent stem cells)—but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.(http://en.wikipedia.org/wiki/Stem_cell)
- Can you explain the difference in skincare benefits between plant stem cells and human stem cells? It is thought that plant based stem cells are not similar enough in the protein structure to that of human skin. The human skin is the largest organ ion the body and it is important that obtaining bioactive molecules from human stem cells is that they are most similar to what is native to human skin and therefore work that much better to help reduce and reverse the signs of aging.
- What is a common myth or misconception about the use of human stem cells? The greatest and most common misconception about the use of human stem cell to derive growth factors; is that they are derived from embryonic fetuses or that an unborn child was harmed. The stem cells that are used to derive the growth factors used in J Bio Serums are developed from healthy donors. There are no embryonic fetuses or unborn children harmed during the process.
- Why is the technology behind J Bio Serums unique; and what is the role human stem derived growth factors? The formulations used in creating J Bio Serums are unique on many levels. This formulation employs a high concentration of bioactive molecules that are derived from the stem cell culture media. The formulation that is used to create J Bio Serums is proprietary. J Bio Serums uses advanced & cutting edge stem cell technology to derive specific and specialized growth factors. Each growth factor is chosen based upon its specific and specialized function; its ability to help restore and maintain the youthful, luminous glow that vibrant skin should have.
- Why are human stem cells a valuable ingredient in J Bio Serums? The human stem cell derived growth factors used in J Bio Serums are a critical ingredient. Each Specific and Specialized growth factor has been chosen for their effectiveness at reducing the signs of aging and restoring and maintaining the youthful, luminous glow that vibrant skin should have.
- Are Human Derived Growth Factors used in Medical Treatments? Medical Studies have shown that certain Human Stem Cell Derived Growth Factors possess the power to be provide potent anti-inflammatory effects that may reduce healing time, hyper pigmentation, and scar tissue deposition. The use of Stem Cell human derived growth factors has been studied in the use for the treatment of burns, wound healing, skin grafting and other skin related issues (4)(5). The results of these studies are very exciting and show a promising future for the use of Human Stem Cell Derived Growth Factors in future medical treatments.
- How else can the stem cell technology be used effectively in a professional setting utilizing growth factors? Regenerative science utilizing adipose derived human stem cells has many applications utilizing many modalities found in physician’s practices and Medical Spas. These modalities are laser and ablative treatments, derma planning, micro-dermabrasion, chemical peels and the use of micro-needling technology also known as collagen induction therapy (CIT). The use of Intense Recovery Serum has shown to help with a patient’s downtime after laser treatments and gain unprecedented results while applying the serum during and after procedures. Additionally, the use of J Bio Intense Recovery Serum during micro needling procedures is gaining significant popularity in medical spas and physicians’ offices with patients wishing to reduce the signs of cystic acne & scarring, photo damage and the signs of aging.
- What do we see as the future for Stem Cell Derived Growth Factors in skin care? The use of human stem cell derived growth factors is the future of skin care. It is our thought that over the next several years physician’s practices and medical spa centers will shift toward the use of cost effective serums that work in a natural way utilizing the technological breakthroughs in the area of human stem cells. Vitacell is optimistic about the future that the technology is heading towards and looking forward to continued success in development of new technologies and applications.
- Thy use Stem Cell Derived Growth Factors Serums as a part of my daily skin care routine? Although we all face different challenges as we age the most common use for using Stem Cell Derived growth Factors as a regular part of your daily skin care regiment may help with the following items of concern:
- Dry Skin
- Thinning Skin
- Crow’s Feet
- Pronounced Laugh Lines
- Age Spots
- Deep wrinkles in forehead & frown line
- Spider Veins
- Sagging Skin
- Longer Healing Time
- Loss of Elasticity
- Eyelash Length and Thickness
(1) Frontiers in Bioscience 9, 283-289, January 1, 2004. Wound Healing: An overview of Acute, Fibrotic and Delayed Healing. Robert F. Diegelmann and Melissa C. Evans. Departments of Biochemistry, Anatomy and Emergency Medicine and Pediatric Critical Care. Medical College of Virginia, Virginia Commonwealth University, Richmond Virginia
(2) “growth factor” at Dorland’s Medical Dictionary
(3) What is human growth hormone (HGH)? Diane Suchetka, Brie Zeltner and Amanda Garrett, The Plain Dealer By Diane Suchetka, Brie Zeltner and Amanda Garrett, The Plain Dealer on October 20, 2012 at 5:59 AM
(4) Annals of Burns and Fire Disasters – vol. XIII – n. 4 – December 2000. ENHANCEMENT OF BURN HEALING BY GROWTH FACTORS AND IL-8 Blumenfeld I.,1 Ullmann Y.,2 Laufer D.,1 Livne E.3 Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel 1 Maxillofacial and Oral Surgery Dept., Rambam Medical Centre 2 Plastic Surgery Dept, Rambam Medical Centre 3 Division of Morphological Sciences
(5) Epidermal Growth Factor in the Treatment of Diabetic Foot Ulcers: An Update. Elisavet K. Tiaka, MD1, Nikolaos Papanas, MD1, Anastassios C. Manolakis, MD2, and George S. Georgiadis, MD1